The following is from a historical document by the CDC; it documents the history of Plague in the United States.
Historically, bubonic plague has been responsible for a number of notable pandemics. The disease appears to have a strong, long-term,
cyclic tendency. It flares up on a global scale and then slowly retreats to smoulder in endemic centers. During the last 15 centuries, four
important pandemics have been recorded: the pandemic of 542 to 600 A. D., which began during the reign of the Emperor Justinian and involved the whole Roman world; the “Black Death” of the 14th century, some of which wascertainly plague, and which caused an estimated loss of 25 million lives, one-fourth of the entire population of Europe alone; the pandemic of the 15th, 16tli, and 17th centuries, which culminated in the “Great Plague of London,” 1664 to 1665; and the present pandemic, which began in 1894 and is now receding. Between pandemics, notable epidemics have been recorded in countries all over the world. There is also reason to believe that there are endemic centers in portions of Africa and Asia, which represent the points of origin of all pandemics (1).
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